At 5 pounds 10 ounces, a bundle of joy was delivered to her 33-year-old mother in São Paulo, Brazil on December 15, 2017. As our eyes turn toward celebrating this young lady’s birthday, a slew of authors1 have published something unique about this birth: to the world’s knowledge it is the first recorded instance of a human child born from a uterus transplanted from a deceased donor. As the authors note, “The results establish proof-of-concept for treating uterine infertility by transplantation from a deceased donor, opening a path to healthy pregnancy for all women.” For more, please consider glancing below. For now, please join me in wishing the birthday girl many more.
From The Lancet:
- In September, 2016, a 32-year-old woman with congenital uterine absence (Mayer-Rokitansky-Küster-Hauser [MRKH] syndrome) underwent uterine transplantation in Hospital das Clínicas, University of São Paulo, Brazil, from a donor who died of subarachnoid haemorrhage. The donor was 45 years old and had three previous vaginal deliveries. The recipient had one in-vitro fertilisation cycle 4 months before transplant, which yielded eight cryopreserved blastocysts.
- The recipient showed satisfactory postoperative recovery and was discharged after 8 days’ observation in hospital. Immunosuppression was induced with prednisolone and thymoglobulin and continued via tacrolimus and mycophenalate mofetil (MMF), until 5 months post-transplantation, at which time azathioprine replaced MMF.
- Caesarean delivery occurred on Dec 15, 2017, near gestational week 36. The female baby weighed 2550 g at birth, appropriate for gestational age, with Apgar scores of 9 at 1 min, 10 at 5 min, and 10 at 10 min, and along with the mother remains healthy and developing normally 7 months post partum.
- The uterus was removed in the same surgical procedure as the livebirth and immunosuppressive therapy was suspended.
- Dani Ejzenberg, Wellington Andraus, Luana Regina Baratelli Carelli Mendes, Liliana Ducatti, Alice Song, Ryan Tanigawa, Vinicius Rocha-Santos, Rubens Macedo Arantes, José Maria Soares Jr, Paulo Cesar Serafini, Luciana Bertocco de Paiva Haddad, Rossana Pulcinelli Francisco, Luiz Augusto Carneiro D’Albuquerque, Edmund Chada Baracat.